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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLL All Species: 27.27
Human Site: T458 Identified Species: 54.55
UniProt: Q9UGP5 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UGP5 NP_037406.1 575 63482 T458 L R Q E G F L T D D L V S Q E
Chimpanzee Pan troglodytes XP_507992 575 63394 T458 L R Q E G F L T D D L V S Q E
Rhesus Macaque Macaca mulatta XP_001110483 575 63575 T458 L R Q Q G F L T D D L V S Q E
Dog Lupus familis XP_850651 576 63314 T459 L R R Q G F L T D D L V S Q E
Cat Felis silvestris
Mouse Mus musculus Q9QXE2 573 62924 T456 L R Q Q G F L T D D L V S Q E
Rat Rattus norvegicus Q5RKI3 573 62383 T456 L R Q Q G F L T D D L V S Q E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511409 1156 126349 E472 L R Q S D L E E L K L G A C D
Chicken Gallus gallus XP_001232209 575 63775 T458 L H E S G F L T D D L V S Q E
Frog Xenopus laevis O57383 334 38275 D226 E D C N F I T D T L V K G D T
Zebra Danio Brachydanio rerio Q6DRD3 336 38547 S228 G F I T D T L S K G D T K F M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785226 410 45521 D302 A L K N Y G K D V T T W E E A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_172522 529 59569 G420 F S T H S E E G T D S G V D T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97 85.4 N.A. 82.4 82.4 N.A. 33.8 66.7 22 21.5 N.A. N.A. N.A. N.A. 20
Protein Similarity: 100 99.6 98.4 91.3 N.A. 88.3 88.8 N.A. 40.2 78 36.7 36.1 N.A. N.A. N.A. N.A. 37.7
P-Site Identity: 100 100 93.3 86.6 N.A. 93.3 93.3 N.A. 26.6 80 0 6.6 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 40 86.6 6.6 13.3 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 29.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 47.4 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 0 0 0 0 0 0 0 0 0 9 0 9 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 9 0 % C
% Asp: 0 9 0 0 17 0 0 17 59 67 9 0 0 17 9 % D
% Glu: 9 0 9 17 0 9 17 9 0 0 0 0 9 9 59 % E
% Phe: 9 9 0 0 9 59 0 0 0 0 0 0 0 9 0 % F
% Gly: 9 0 0 0 59 9 0 9 0 9 0 17 9 0 0 % G
% His: 0 9 0 9 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 9 0 0 9 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 9 0 0 0 9 0 9 9 0 9 9 0 0 % K
% Leu: 67 9 0 0 0 9 67 0 9 9 67 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 0 17 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 50 34 0 0 0 0 0 0 0 0 0 59 0 % Q
% Arg: 0 59 9 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 9 0 17 9 0 0 9 0 0 9 0 59 0 0 % S
% Thr: 0 0 9 9 0 9 9 59 17 9 9 9 0 0 17 % T
% Val: 0 0 0 0 0 0 0 0 9 0 9 59 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _